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Importantly, LBM remained largely stable, with slight gains in leg and arm FFM in some patients, resulting in minimal changes in skeletal muscle index and no cases of sarcopenia

But the reduction is often disproportionate, hitting protein intake harder than other macronutrients because protein-rich foods tend to be the most satiating and the hardest to consume when appetite is suppressed

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While many of these side effects lessen over time, some users discontinue treatment due to persistent discomfort